WDFY2 Polyclonal Antibody

PROF, Propeller-FYVE protein, RP11 147H23.1, WD repeat and FYVE domain containing 2, WD repeat and FYVE domain-containing protein 2, WD40 and FYVE domain containing 2, WD40- and FYVE domain-containing protein 2, WDF2, Wdfy2, WDFY2, ZFYVE22, Zinc finger FYVE domain-containing protein 22

WD repeat and FYVE domain-containing protein 2 (WDFY2), also known as WDF2 and ZFYVE22, is a 400 amino acid protein that localizes to a set of small endosomes that are found within 100 nm from the plasma membrane. Highly conserved between species, WDFY2 consists of one FYVE-type zinc finger and seven WD repeats. The FYVE domain is a cysteine-rich domain of about 70 amino acids. Its primary role is to target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate with high specificity. WD-repeats are generally found in clusters of seven. They have no intrinsic catalytic activity, but they serve as a platform for protein-protein interactions. WDFY2 is suspected to play a critical role in the endocytic pathway.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

45 kDa

BC014004