Item no. |
E-AB-15460-120 |
Manufacturer |
Elabscience
|
Amount |
120uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, IHC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
2 aminoethanethiol dioxygenase, 2-aminoethanethiol dioxygenase, ADO 2 aminoethanethiol (cysteamine) dioxygenase, ADO, AEDO, C10orf22, Chromosome 10 open reasing frame 22, cysteamine (2-aminoethanethiol) dioxygenase (ADO), Cysteamine dioxygenase, DKFZp564C |
Similar products |
ADO, C10orf22, DKFZp564C046, FLJ14547, cysteamine (2-aminoethanethiol) dioxygenase (ADO), AEDO, 2-aminoethanethiol dioxygenase, 2 aminoethanethiol dioxygenase, ADO 2 aminoethanethiol (cysteamine) dioxygenase, Chromosome 10 open reasing frame 22, Cysteamine dioxygenase |
Available |
|
Research Areas |
Metabolism, Signal Transduction |
Synonyms |
2 aminoethanethiol dioxygenase, 2-aminoethanethiol dioxygenase, ADO 2 aminoethanethiol (cysteamine) dioxygenase, ADO, AEDO, C10orf22, Chromosome 10 open reasing frame 22, cysteamine (2-aminoethanethiol) dioxygenase (ADO), Cysteamine dioxygenase, DKFZp564C046, FLJ14547 |
Swissprot |
Q96SZ5 |
Background |
Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity. |
Concentration |
0.3 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Synthetic peptide of human ADO |
Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method |
Affinity purification |
Dilution |
WB 1:1000-1:5000, IHC 1:25-1:100 |
Conjugation |
Unconjugated |
Calculated MW |
30kDa |
Gene Accession |
NP_116193 |
Santa Cruz # |
sc-162492, sc-162493 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.