ANAPC2 Polyclonal Antibody

anapc2, Anaphase promoting complex subunit 2, Anaphase-promoting complex subunit 2, ANC2, APC2, Cyclosome subunit 2, KIAA1406, OTTHUMP00000022692, RP11 350O14.5

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, whicHuman, Mouseay also be involved in ubiquitin-mediated degradation.

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

IHC 1:50-1:200

BC032503