IGF2R Polyclonal Antibody

300 kDa mannose 6 phosphate receptor, 300 kDa mannose 6-phosphate receptor, Cation independent mannose 6 phosphate receptor, Cation-independent mannose-6-phosphate receptor, CD222, CD222 antigen, CI Man 6 P receptor, CI Man-6-P receptor, CI MPR, CI-M6PR, CI-MPR, CIMPR, IGF 2 receptor, IGF 2R, IGF II receptor, IGF-II receptor, IGF2 receptor, Igf2r, Insulin like growth factor 2 receptor, Insulin like growth factor II receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P R, M6P/IGF2 receptor, M6P/IGF2R, M6PR, mannose 6 phosphate receptor, mannose 6 phosphate receptor, cation independent, MPR 300, MPR300, MPRI, MPRI

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611).

Store at -20C. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

WB 1:500 - 1:2000

274kDa