Item no. |
E-AB-52149-20 |
Manufacturer |
Elabscience
|
Amount |
20uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
WB, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Docking protein 3, DOK 3, DOK Like Protein, Dok3, DOK3, DOKL Pending, Downstream of tyrosine kinase 3, p62 DOK Like Protein |
Similar products |
DOK3, Docking protein 3, Downstream of tyrosine kinase 3, Dok3, DOK 3, DOK Like Protein, DOKL Pending, p62 DOK Like Protein |
Available |
|
Research Areas |
Cancer, Signal Transduction |
Synonyms |
Docking protein 3, DOK 3, DOK Like Protein, Dok3, DOK3, DOKL Pending, Downstream of tyrosine kinase 3, p62 DOK Like Protein |
Swissprot |
Q7L591 |
Background |
DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function |
Concentration |
0.4 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human DOK3 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
WB 1:500-1:2000, ELISA 1:1000-1:5000 |
Conjugation |
Unconjugated |
Calculated MW |
53 kDa |
Observed MW |
Refer to figures |
Gene Accession |
BC004564 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.