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CRACR2A Polyclonal Antibody

CRACR2A Polyclonal Antibody

Item no.	E-AB-19269-20
Manufacturer	Elabscience
Amount	20uL
Category	Antibodies Immunohistochemistry ELISA Cardiovascular Research Myocardial Infarction Primary Antibodies
Type	Antibody Polyclonal
Applications	IHC, ELISA
Specific against	Human
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efc
Similar products	CRACR2A, EF-hand calcium-binding domain-containing protein 4B, Calcium release-activated calcium channel regulator 2A, FLJ33805, MGC4266, Efcab4b, EFC4B, CRAC channel regulator 2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EFCAB 4B
Available
Research Areas	Signal transduction
Synonyms	Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efcab4b, FLJ33805, MGC4266
Swissprot	Q9BSW2
Background	Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Concentration	0.84 mg/mL
Storage	Store at -20C. Avoid freeze / thaw cycles.
Immunogen	Fusion protein of human CRACR2A
Buffer	PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method	Antigen affinity purification
Dilution	IHC 1:50-1:200, ELISA 1:5000-1:10000
Conjugation	Unconjugated
Gene Accession	BC004524

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20uL

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Delivery expected until 9/6/2024

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