Item no. |
E-AB-18660-60 |
Manufacturer |
Elabscience
|
Amount |
60uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DR 9, DR beta 5, DR beta 5 chain, DR beta-5, DR beta5, DR2 beta 2, DR2-beta-2, DR9, DRB5, Dw2, FLJ76359, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR beta 5 chain, HLA class II histocompatibility antigen DRB1-9 beta |
Similar products |
HLA-DRB5, HLA class II histocompatibility antigen, DRB5, class II, DR beta 5 chain, DR-5 beta chain, MHC HLA-DR-beta cell surface glycoprotein, MHC HLA-DR-beta chain, MHC class II HLA beta chain, Major histocompatibility complex, FLJ76359, DR 9, DR beta 5, DR beta-5, DR beta5, DR2 beta 2, DR2-beta-2, DR9, Dw2, HLA class II histocompatibility antigen DR beta 5 chain, HLA class II histocompatibility antigen DRB1-9 beta chain, HLA DRB, Human leucocyte antigen DRB5, Leukocyte antigen class II, DR beta 51, MHC class II antigen DRB1*9, MHC class II antigen DRB5 |
Available |
|
Research Areas |
Immunology |
Synonyms |
DR 9, DR beta 5, DR beta 5 chain, DR beta-5, DR beta5, DR2 beta 2, DR2-beta-2, DR9, DRB5, Dw2, FLJ76359, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR beta 5 chain, HLA class II histocompatibility antigen DRB1-9 beta chain, HLA class II histocompatibility antigen, DR-5 beta chain, HLA DRB, HLA-DRB5, Human leucocyte antigen DRB5, Leukocyte antigen class II, Major histocompatibility complex, class II, DR beta 51, MHC class II antigen DRB1*9, MHC class II antigen DRB5, MHC class II HLA beta chain, MHC HLA-DR-beta cell surface glycoprotein, MHC HLA-DR-beta chain |
Swissprot |
Q30154 |
Background |
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |
Concentration |
1.62 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Fusion protein of human HLA-DRB5 |
Buffer |
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
Purification Method |
Antigen affinity purification |
Dilution |
IHC 1:40-1:200, ELISA 1:5000-1:10000 |
Conjugation |
Unconjugated |
Gene Accession |
BC009234 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.