Item no. |
E-AB-10674-120 |
Manufacturer |
Elabscience
|
Amount |
120uL |
Category |
|
Type |
Antibody Polyclonal |
Applications |
IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Tax responsive element binding protein 5, Tax-responsive element-binding protein 5, TREB5, X box binding protein 1, X box binding protein 2, X-box-binding protein 1, XBP 1, XBP-1, XBP1, XBP1, XBP2 |
Similar products |
XBP-1, XBP1, TREB5, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5, Tax responsive element binding protein 5, X box binding protein 1, X box binding protein 2, XBP 1 |
Available |
|
Research Areas |
Cancer, Epigenetics and Nuclear Signaling |
Synonyms |
Tax responsive element binding protein 5, Tax-responsive element-binding protein 5, TREB5, X box binding protein 1, X box binding protein 2, X-box-binding protein 1, XBP 1, XBP-1, XBP1, XBP1, XBP2 |
Swissprot |
P17861 |
Background |
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. |
Concentration |
0.2 mg/mL |
Storage |
Store at -20C. Avoid freeze / thaw cycles. |
Immunogen |
Recombinant protein of human XBP1 |
Buffer |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method |
Affinity purification |
Dilution |
IHC 1:50-1:200 |
Conjugation |
Unconjugated |
Gene Accession |
BC000938 |
Santa Cruz # |
sc-32138, sc-32135, sc-32136, sc-7160 |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.