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Recombinant Human Vascular cell adhesion protein 1(VCAM1),partial

Recombinant Human Vascular cell adhesion protein 1(VCAM1),partial

Item no.	CSB-YP025809HU-1
Manufacturer	Cusabio
Amount	1mg
Category	Oncology Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins By Organ Renal Cancer
Type	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	Yeast
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	INCAM-100; CD106
Available
Research Topic	Cell Adhesion
Uniprot ID	P19320
Gene Names	VCAM1
Organism	Homo sapiens (Human)
AA Sequence	FKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSW RTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL CTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEA GKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEF LEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKL HIDEMDSVPTVRQAVKELQVYISPKNTVISVNPST KLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQH LSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEV ELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMG CESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVS FENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEI EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGE TILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGK ALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDT TVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQ AGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTV IISCTCGNVPETWIILKKKAETGDTVLKSIDGAYT IRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRE NNKDYFSPE
Expression Region	25-698aa
Sequence Info	Extracellular Domain
Source	Yeast
Tag Info	N-terminal 6xHis-tagged
MW	76.2 kDa
Alternative Name(s)	INCAM-100; CD106
Relevance	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte igration to sites of inflammation.
Reference	Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R.Cell 59:1203-1211(1989)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subcellular Location	Membrane, Single-pass type I membrane protein
Tissue Specificity	Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Paythway	LipidsandInflammation inAtherogenesis
Tag Information	N-terminal 6xHis-tagged

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