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Recombinant Human Alpha-synuclein(SNCA)

Recombinant Human Alpha-synuclein(SNCA)

Item no.	CSB-YP021912HU-50
Manufacturer	Cusabio
Amount	50ug
Category	Neuroscience Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	Yeast
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Non-A beta component of AD amyloidNon-A4 component of amyloid precursor ;NACP
Available
Research areas	Neuroscience
Target / Protein	SNCA
Biologically active	Not Test
Expression system	Yeast
Species of origin	Homo sapiens (Human)
Uniprot ID	P37840
AA Sequence	MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKE GVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAV VTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEE GAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
Tag Info	N-terminal 6xHis-tagged
Expression Region	1-140aa
Protein length	Full Length
MW	16.5 kDa
Alternative Name(s)	Non-A beta component of AD amyloidNon-A4 component of amyloid precursor ; NACP
Relevance	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
References	Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.Ueda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A., Kondo J., Ihara Y., Saitoh T.Proc. Natl. Acad. Sci. U.S.A. 90:11282-11286(1993)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Involvement in disease	Parkinson disease 1, autosomal dominant (PARK1); Parkinson disease 4, autosomal dominant (PARK4); Dementia Lewy body (DLB)
Subcellular Location	Cytoplasm, cytosol, Membrane, Nucleus, Cell junction, synapse, Secreted
Protein Families	Synuclein family
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Tag Information	N-terminal 6xHis-tagged

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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