Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
200ug |
Host |
Yeast |
Item no. |
CSB-YP011930HU-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Alias |
Janus kinase 1,Short name:,JAK-1 |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Research Topic |
Cancer |
Uniprot ID |
P23458 |
Gene Names |
JAK1 |
Organism |
Homo sapiens (Human) |
AA Sequence |
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEG HFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHI ADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKL IMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICK GMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGL TKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY IASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGP THGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMR KCWEFQPSNRTSFQNLIEGFEALLK |
Expression Region |
850-1154aa |
Sequence Info |
Partial |
Source |
Yeast |
Tag Info |
N-terminal 6xHis-tagged |
MW |
36.9 kDa |
Alternative Name(s) |
Janus kinase 1 Short name: JAK-1 |
Relevance |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
Reference |
"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase." Wilks A.F., Harpur A.G., Kurban R.R., Ralph S.J., Zuercher G., Ziemiecki A.Mol. Cell. Biol. 11:2057-2065(1991) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway |
Subcellular Location |
Endomembrane system, Peripheral membrane protein |
Protein Families |
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily |
Tissue Specificity |
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.