Item no. |
CSB-YP009196HU-1 |
Manufacturer |
Cusabio
|
Amount |
1mg |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
Yeast |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Galactocerebroside beta-galactosidase,Galactosylceramidase,Galactosylceramide beta-galactosidase |
Available |
|
Research Topic |
Cardiovascular |
Uniprot ID |
P54803 |
Gene Names |
GALC |
Organism |
Homo sapiens (Human) |
AA Sequence |
YVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEP YRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGT EPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLI GLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIVGA KRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQG LQRVKIIASDNLWESISASMLLDAELFKVVDVIGA HYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGC WGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRC GLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYY LKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHS KCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWY TKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDE LFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVD YPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQ VLNQRPITWAADASNTISIIGDYNWTNLTIKCDVY IETPDTGGVFIAGRVNKGGILIRSARGIFFWIFAN GSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIK GHFASGMLNDKSLWTDIPVNFPKNGWAAIGTHSFE FAQFDNFLVEATR |
Expression Region |
43-685aa |
Sequence Info |
Full Length of Mature Protein |
Source |
Yeast |
Tag Info |
N-terminal 6xHis-tagged |
MW |
74.8 kDa |
Alternative Name(s) |
Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase |
Relevance |
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. |
Reference |
"Structure and organization of the human galactocerebrosidase (GALC) gene."Luzi P., Rafi M.A., Wenger D.A.Genomics 26:407-409(1995) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. |
Involvement in disease |
Leukodystrophy, globoid cell (GLD) |
Subcellular Location |
Lysosome |
Protein Families |
Glycosyl hydrolase 59 family |
Tissue Specificity |
Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver. |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.