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Recombinant Human Muscarinic acetylcholine receptor M3(CHRM3),partial

Recombinant Human Muscarinic acetylcholine receptor M3(CHRM3),partial

Item no.	CSB-YP005383HU-200
Manufacturer	Cusabio
Amount	200ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	Yeast
Purity	Greater than 90% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Research Topic	Neuroscience
Uniprot ID	P20309
Gene Names	CHRM3
Organism	Homo sapiens (Human)
AA Sequence	RIYKETEKRTKELAGLQASGTEAETENFVHPTGSS RSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKP SSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDI GSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVP EEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKL PIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEAT LAKRFALKTRSQITKRKRMSLVKEKKAAQT
Expression Region	253-492aa
Sequence Info	Cytoplasmic Domain
Source	Yeast
Tag Info	N-terminal 6xHis-tagged
MW	28.7 kDa
Relevance	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Reference	Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J., Capon D.J.EMBO J. 6:3923-3929(1987)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Involvement in disease	Prune belly syndrome (PBS)
Subcellular Location	Cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Basolateral cell membrane, Multi-pass membrane protein
Protein Families	G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM3 sub-subfamily
Paythway	Calciumsignalingpathway
Tag Information	N-terminal 6xHis-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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