Item no. |
CSB-YP004929HU1c7-500 |
Manufacturer |
Cusabio
|
Amount |
500ug |
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Research areas |
Cancer |
Target / Protein |
CD38 |
Biologically active |
Not Test |
Expression system |
Yeast |
Species of origin |
Homo sapiens (Human) |
Uniprot ID |
P28907 |
AA Sequence |
VPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEM RHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKL GTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLED TLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSN NPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFD KNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRD LCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQC VKNPEDSSCTSEI |
Tag Info |
C-terminal 6xHis-tagged |
Expression Region |
43-300aa |
Protein length |
Partial |
MW |
30.7 kDa |
Alternative Name(s) |
2'-phospho-ADP-ribosyl cyclase (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPr hydrolase 1) (T10) (CD_antigen: CD38) |
Relevance |
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
References |
"Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing." Nata K., Takamura T., Karasawa T., Kumagai T., Hashioka W., Tohgo A., Yonekura H., Takasawa S., Nakamura S., Okamoto H. Gene 186:285-292(1997) |
Purity |
Greater than 85% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. |
Subcellular Location |
Membrane, Single-pass type II membrane protein |
Protein Families |
ADP-ribosyl cyclase family |
Tissue Specificity |
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. |
Paythway |
Calciumsignalingpathway |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.