Item no. |
CSB-EP020669MOa0-500 |
Manufacturer |
Cusabio
|
Amount |
500ug |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Purity |
Greater than 85% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Research Topic |
Signal Transduction |
Uniprot ID |
P20443 |
Gene Names |
Sag |
Organism |
Mus musculus (Mouse) |
AA Sequence |
MAACGKTNKSHVIFKKVSRDKSVTIYLGKRDYVDH VSQVEPVDGVVLVDPELVKGKKVYVTLTCAFRYGQ EDIDVMGLTFRRDLYFSRVQVYPPVGAMSVLTQLQ ESLLKKLGDNTYPFLLTFPDYLPCSVMLQPAPQDV GKSCGVDFEVKAFASDITDPEEDKIPKKSSVRLLI RKVQHAPPEMGPQPSAEASWQFFMSDKPLNLSVSL SKEIYFHGEPIPVTVTVTNNTDKVVKKIKVSVEQI ANVVLYSSDYYVKPVASEETQEKVQPNSTLTKTLV LVPLLANNRERRGIALDGKIKHEDTNLASSTIIKE GIDRTVMGILVSYHIKVKLTVSGFLGELTSSEVAT EVPFRLMHPQPEDPAKESVQDENLVFEEFARQNLK DTGENTEGKKDEDAGQDE |
Expression Region |
1-403aa |
Sequence Info |
Full Length |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
50.4 kDa |
Alternative Name(s) |
48 kDa protein (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) |
Relevance |
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells |
Reference |
"Deactivation of phosphorylated and nonphosphorylated rhodopsin by arrestin splice variants." Burns M.E., Mendez A., Chen C.K., Almuete A., Quillinan N., Simon M.I., Baylor D.A., Chen J. J. Neurosci. 26:1036-1044(2006) |
Purity |
Greater than 85% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO |
Subcellular Location |
Cell projection, cilium, photoreceptor outer segment, Membrane, Peripheral membrane protein |
Protein Families |
Arrestin family |
Tissue Specificity |
Detected in retina (at protein level). |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.