Item no. |
CSB-EP015836HU-50 |
Manufacturer |
Cusabio
|
Amount |
50ug |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Research Topic |
Cell Biology |
Uniprot ID |
O15226 |
Gene Names |
NKRF |
Organism |
Homo sapiens (Human) |
AA Sequence |
ILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCD GQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQE DPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQ DGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPST TSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLT ATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTN PEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQN IYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVV RRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLV VLGKDASGQPIFNASAKHWTNFVITENANDAIGIL NNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLA EGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQ CHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDT AQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAV GVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVE DVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMG WTGGGLGKSGEGIREPISVKEQHKREGLGLDVERV NKIAKRDIEQIIRNYARSESHTDLTFSRELTNDER KQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKED LLDQLKQEGQVGHYELVMPQ |
Expression Region |
4-688aa |
Sequence Info |
Partial |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
81.1 kDa |
Alternative Name(s) |
Protein ITBA4Transcription factor NRF |
Relevance |
Interacts with a specific negative regulatory elent (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. |
Reference |
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. |
Subcellular Location |
Nucleus, nucleolus |
Tissue Specificity |
Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney. |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.