Item no. |
CSB-EP013308RA-200 |
Manufacturer |
Cusabio
|
Amount |
200ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 5.1 |
34160400 |
ECLASS 6.1 |
34160400 |
ECLASS 8.0 |
42020190 |
ECLASS 9.0 |
42020190 |
ECLASS 10.0.1 |
32160409 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Short name:,MAdCAM-1,Short name:,rMAdCAM-1 |
Available |
|
Research Topic |
Immunology |
Uniprot ID |
O70540 |
Gene Names |
Madcam1 |
Organism |
Rattus norvegicus (Rat) |
AA Sequence |
QSFQVNPPEPEVAVAMGTSLQINCSMSCDKDIARV HWHGLDTNLGNVQTLPGSRVLSVRGMLSDTGTRVC VGSCGSRSFQHSVKILVYAFPDQLEVTPEFLVPGR DQVVSCTAHNIWPAGPDSLSFALLRGEQSLEGAQA LETEQEEEMQETEGTPLFQVTQRWLLPSLGTPALP ALYCQVTMQLPKLVLTHRRKIPVLQSQTSPEPPST TSAKPYILTSSHTTKAVSTGLSSVALPSTPLSSEG PCYPEIHQNPEADWELLCEASCGSGVTVHWTLAPG DLAAYHKREAGAQAWLSVLPLGPIPEGWFQCRMDP GGQVTSLYVTGQVIPNPSS |
Expression Region |
20-353aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
52 kDa |
Alternative Name(s) |
Short name: MAdCAM-1 Short name: rMAdCAM-1 |
Relevance |
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes |
Reference |
"Cloning and characterization of the rat MAdCAM-1 cDNA and gene."Iizuka T., Koike R., Miyasaka N., Miyasaka M., Watanabe T.Biochim. Biophys. Acta 1395:266-270(1998) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes (By similarity). |
Subcellular Location |
Membrane, Single-pass type I membrane protein |
Tissue Specificity |
Detected in Peyer patches and mesenteric lymph nodes but not in spleen. |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.