Item no. |
CSB-EP011930MO-100 |
Manufacturer |
Cusabio
|
Amount |
100ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Janus kinase 1,Short name:,JAK-1 |
Available |
|
Research Areas |
Others |
Uniprot ID |
P52332 |
Gene Names |
Jak1 |
Organism |
Mus musculus (Mouse) |
AA Sequence |
EEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGE GHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNH IADLKKEIEILRNLYHENIVKYKGICMEDGGNGIK LIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQIC KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFG LTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKF YIASDVWSFGVTLHELLTYCDSDFSPMALFLKMIG PTHGQMTVTRLVKTLKEGKRLPCPPNCPDEVYQLM RKCWEFQPSNRTTFQNLIEGFEALL |
Expression Region |
848-1152aa |
Sequence Info |
Partial |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
39.1 kDa |
Alternative Name(s) |
Janus kinase 1 Short name: JAK-1 |
Relevance |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
Reference |
Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system.Yang X., Chung D., Cepko C.L.J. Neurosci. 13:3006-3017(1993) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Form |
Liquid or Lyophilized powder |
Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. |
Subcellular Location |
Endomembrane system, Peripheral membrane protein |
Protein Families |
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.