Item no. |
CSB-EP007140RA-1 |
Manufacturer |
Cusabio
|
Amount |
1mg |
Quantity options |
1mg
10ug
100ug
20ug
200ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
DPPXDipeptidyl aminopeptidase-related proteinDipeptidyl peptidase 6Dipeptidyl peptidase IV-like proteinDipeptidyl peptidase VI ;DPP VI |
Available |
|
Research Areas |
Others |
Uniprot ID |
P46101 |
Gene Names |
DPP6 |
Organism |
Rattus norvegicus (Rat) |
AA Sequence |
LTPAEDTSLSQKKKVTVEDLFSEDFKIHDPEAKWI SDKEFIYRERKGSVILRNVETNNSTVLIEGKKIES LRAIRYEISPDKEYALFSYNVEPVYQHSHTGYYVL SKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIF IFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDW LYEEEILKSHIAHWWSPDGTRLAYATINDSRVPLM ELPTYTGSVYPTVKPYHYPKAGSENPSISLHVIGL NGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAV TWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLH RQNEEPVFSKDGRKFFFVRAIPQGGRGKFYHITVS SSQPNSSNDNIQSITSGDWDVTEILTYDEKRNKLY FLSTEDLPRRRHLYSANTVDDFNRQCLSCDLVENC TYVSASFSHNMDFFLLKCEGPGVPTVTVHNTTDKR RMFDLEANEQVQKAIYDRQMPKIEYRKIEVEDYSL PMQILKPATFTDTAHYPLLLVVDGTPGSQSVSERF EVTWETVLVSSHGAVVVKCDGRGSGFQGTKLLHEV RRRLGFLEEKDQMEAVRTMLKEQYIDKTRVAVFGK DYGGYLSTYILPAKGENQGQTFTCGSALSPITDFK LYASAFSERYLGLHGLDNRAYEMTKLAHRVSALED QQFLIIHATADEKIHFQHTAELITQLIKGKANYSL QIYPDESHYFHSVALKQHLYRSIIGFFVECFRIQD KLPTATAKEDEEED |
Expression Region |
111-859aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
89.6 kDa |
Alternative Name(s) |
DPPXDipeptidyl aminopeptidase-related proteinDipeptidyl peptidase 6Dipeptidyl peptidase IV-like proteinDipeptidyl peptidase VI ; DPP VI |
Relevance |
Promotes cell surface expression of the potassium channel KCND2 . Modulates the activity and gating characteristics of the potassium channel KCND2 . Has no dipeptidyl aminopeptidase activity . |
Reference |
The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.Kaulin Y.A., De Santiago-Castillo J.A., Rocha C.A., Nadal M.S., Rudy B., Covarrubias M.J. Neurosci. 29:3242-3251(2009) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Form |
Liquid or Lyophilized powder |
Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Promotes cell surface expression of the potassium channel KCND2 |
Subcellular Location |
Cell membrane, Single-pass type II membrane protein |
Protein Families |
Peptidase S9B family |
Tissue Specificity |
Detected in brain cortex, hippocampus, thalamus and cerebellum granule cells (at protein level) (PubMed:16123112). Isoform DPPX-S is expressed in brain and some peripheral tissues including kidney, ovary, and testis; in contrast isoform DPPX-L is expressed almost exclusively in brain. |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.