Item no. |
CSB-EP005599HU-200 |
Manufacturer |
Cusabio
|
Amount |
200ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Liquid or Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
Greater than 90% as determined by SDS-PAGE. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Alpha-chymase,Mast cell protease I |
Available |
|
Research Topic |
Cardiovascular |
Uniprot ID |
P23946 |
Gene Names |
CMA1 |
Organism |
Homo sapiens (Human) |
AA Sequence |
IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLI RRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKL EVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAV GTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDT LQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTK SAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFT RISHYRPWINQILQAN |
Expression Region |
22-247aa |
Sequence Info |
Full Length of Mature Protein |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-tagged |
MW |
29 kDa |
Alternative Name(s) |
Alpha-chymase Mast cell protease I |
Relevance |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, Extracellular domain matrix degradation, and regulation of gland secretion. |
Reference |
"Cloning of the gene and cDNA for human heart chymase."Urata H., Kinoshita A., Perez D.M., Misono K.S., Bumpus F.M., Graham R.M., Husain A.J. Biol. Chem. 266:17173-17179(1991) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. |
Subcellular Location |
Secreted, Cytoplasmic granule |
Protein Families |
Peptidase S1 family, Granzyme subfamily |
Tissue Specificity |
Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. |
Paythway |
Renin-angiotensinsystem |
Tag Information |
N-terminal 6xHis-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.