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Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)

Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)

Item no.	CSB-AP003491HO-5
Manufacturer	Cusabio
Amount	5ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>95% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Interleukin-1 receptor antagonist protein,Short name:,IL-1RN,Short name:,IL-1ra,Short name:,IRAP,Alternative name(s):,IL1 inhibitor
Available
Classification	Cytokine
Subdivision	Interleukin
Research Areas	Immunology
Uniprot NO.	O18999
Uniprot Entry Name	IL1RA_HORSE
Gene Names	IL1RN
Source	E.Coli
Expression Region	26-177aa
Sequence	HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VA GYLQESNT KLQEKIDVVP IEPDALFLGL HGRK LCLACV KSGDEIRFQL EAVNITDLSK NKEENK RFTF IRSNSGPTTS FESAACPGWF LCTAQEAD RP VSLTNKPKES FMVTKFYLQE DQ
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	17.4 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 3.0 ug/ml, corresponding to a specific activity of ? 333 IU/mg in the presence of 50 pg/ml rHuIL-1alpha.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor
Relevance	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
PubMed ID	19157767
Function	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Subcellular Location	Secreted
Protein Families	IL-1 family
Tag Information	Tag-Free

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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