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Recombinant Mouse Interleukin-21 protein(Il21) (Active)

Recombinant Mouse Interleukin-21 protein(Il21) (Active)

Item no.	CSB-AP003391MO-250
Manufacturer	Cusabio
Amount	250ug
Quantity options	1mg 10ug 100ug 2ug 250ug 500ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>98% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IL-21,
Available
Classification	Cytokine
Subdivision	Interleukin
Research Areas	Immunology
Uniprot NO.	Q9ES17
Uniprot Entry Name	IL21_MOUSE
Gene Names	Il21
Source	E.Coli
Expression Region	18-146aa
Sequence	HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DL DPELLSAP QDVKGHCEHA AFACFQKAKL KPSN PGNNKT FIIDLVAQLR RRLPARRGGK KQKHIA KCPS CDSYEKRTPK EFLERLKWLL QKMIHQHL
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	15.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of ? 4.0 x 104 IU/mg.
Purity	>98% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 m filtered 2 x PBS, pH 7.4 , lyophilized
Alias	IL-21,
Relevance	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269\|PubMed:11970879, ECO:0000269\|PubMed:12893770, ECO:0000269\|PubMed:15100251}.
PubMed ID	11081504; 11970879; 12893770; 15100251
Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Subcellular Location	Secreted
Protein Families	IL-15/IL-21 family
Tag Information	Tag-Free

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