Item no. |
CSB-AP003071MOW-100 |
Manufacturer |
Cusabio
|
Amount |
100ug |
Quantity options |
1mg
10ug
100ug
2ug
250ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IL-1 alpha, |
Available |
|
Classification |
Cytokine |
Subdivision |
Interleukin |
Research Areas |
Immunology |
Uniprot NO. |
P48089 |
Uniprot Entry Name |
IL1A_MACMU |
Gene Names |
IL1A |
Source |
E.Coli |
Expression Region |
113-271aa |
Sequence |
SAPFSFLSNM TYHFIRIIKH EFILNDTLNQ TI IRANDQHL TAAAIHNLDE AVKFDMGAYT SSKD DTKVPV ILRISKTQLY VSAQDEDQPV LLKEMP EINK TITGSETNFL FFWETHGTKN YFISVAHP NL FIATKHDNWV CLAKGLPSIT DFQILENQA |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
18.1 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 10 pg/ml, corresponding to a specific activity of ? 1.0 x 108 IU/mg. |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
IL-1 alpha, |
Relevance |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
PubMed ID |
7561102 |
Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
Subcellular Location |
Secreted |
Protein Families |
IL-1 family |
Tag Information |
Tag-Free |
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