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Recombinant Human Insulin-like growth factor II protein(IGF2) (Active)

Recombinant Human Insulin-like growth factor II protein(IGF2) (Active)

Item no.	CSB-AP002551HU-250
Manufacturer	Cusabio
Amount	250ug
Quantity options	1mg 10ug 100ug 250ug 50ug 500ug
Category	Neuroscience Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Molecular Targets for Neuroscience Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	other
Host	E.coli
Purity	>98% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	IGF-II, T3M-11-derived growth factor,
Available
Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Cancer
Uniprot NO.	P01344
Uniprot Entry Name	IGF2_HUMAN
Gene Names	IGF2, PP1446
Source	E.Coli
Expression Region	25-91aa
Sequence	AYRPSETLCG GELVDTLQFV CGDRGFYFSR PA SRVSRRSR GIVEECCFRS CDLALLETYC ATPA KSE
Protein Description	Partial
Tag Info	Tag-Free
Mol. Weight	7.5 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg.
Purity	>98% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150 mM NaCl, with 0.02 % Tween-20 , lyophilized
Alias	IGF-II, T3M-11-derived growth factor,
Relevance	The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
PubMed ID	6382022; 6382021; 2450353; 3002851; 3476948; 3683205; 3881277; 7730145; 16531418; 20842449; 15498874; 14702039; 16554811; 15489334; 3167054; 3653397; 3652904; 658418; 2722836; 7633596; 11448941; 12586351; 15359740; 1569071; 16912056; 19066168; 19838169; 22171320; 23234360; 6189745; 7527339; 18046459
Function	The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable).
Involvement in disease	Silver-Russell syndrome (SRS); Growth restriction, severe, with distinctive facies (GRDF)
Subcellular Location	Secreted
Protein Families	Insulin family
Tissue Specificity	Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
Paythway	MAPKsignalingpathway
Tag Information	Tag-Free

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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