Item no. |
CSB-AP002551HU-250 |
Manufacturer |
Cusabio
|
Amount |
250ug |
Quantity options |
1mg
10ug
100ug
250ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
other |
Host |
E.coli |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IGF-II, T3M-11-derived growth factor, |
Available |
|
Classification |
Cytokine |
Subdivision |
Growth Factor |
Research Areas |
Cancer |
Uniprot NO. |
P01344 |
Uniprot Entry Name |
IGF2_HUMAN |
Gene Names |
IGF2, PP1446 |
Source |
E.Coli |
Expression Region |
25-91aa |
Sequence |
AYRPSETLCG GELVDTLQFV CGDRGFYFSR PA SRVSRRSR GIVEECCFRS CDLALLETYC ATPA KSE |
Protein Description |
Partial |
Tag Info |
Tag-Free |
Mol. Weight |
7.5 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using serum free human MCF-7 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 x 105 IU/mg. |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered 20 mM Tris-HCl, pH 8.0, 150 mM NaCl, with 0.02 % Tween-20 , lyophilized |
Alias |
IGF-II, T3M-11-derived growth factor, |
Relevance |
The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.; Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. |
PubMed ID |
6382022; 6382021; 2450353; 3002851; 3476948; 3683205; 3881277; 7730145; 16531418; 20842449; 15498874; 14702039; 16554811; 15489334; 3167054; 3653397; 3652904; 658418; 2722836; 7633596; 11448941; 12586351; 15359740; 1569071; 16912056; 19066168; 19838169; 22171320; 23234360; 6189745; 7527339; 18046459 |
Function |
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). |
Involvement in disease |
Silver-Russell syndrome (SRS); Growth restriction, severe, with distinctive facies (GRDF) |
Subcellular Location |
Secreted |
Protein Families |
Insulin family |
Tissue Specificity |
Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas. |
Paythway |
MAPKsignalingpathway |
Tag Information |
Tag-Free |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.