Item no. |
CSB-AP003391MO-500 |
Manufacturer |
Cusabio
|
Amount |
500ug |
Quantity options |
1mg
10ug
100ug
2ug
250ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Mouse |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Classification |
Cytokine |
Subdivision |
Interleukin |
Research Areas |
Immunology |
Uniprot NO. |
Q9ES17 |
Uniprot Entry Name |
IL21_MOUSE |
Gene Names |
Il21 |
Source |
E.Coli |
Expression Region |
18-146aa |
Sequence |
HKSSPQGPDR LLIRLRHLID IVEQLKIYEN DL DPELLSAP QDVKGHCEHA AFACFQKAKL KPSN PGNNKT FIIDLVAQLR RRLPARRGGK KQKHIA KCPS CDSYEKRTPK EFLERLKWLL QKMIHQHL |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
15.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 25 ng/ml, corresponding to a specific activity of ? 4.0 x 104 IU/mg. |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 m filtered 2 x PBS, pH 7.4 , lyophilized |
Alias |
IL-21, |
Relevance |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269|PubMed:11970879, ECO:0000269|PubMed:12893770, ECO:0000269|PubMed:15100251}. |
PubMed ID |
11081504; 11970879; 12893770; 15100251 |
Function |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. |
Subcellular Location |
Secreted |
Protein Families |
IL-15/IL-21 family |
Tag Information |
Tag-Free |
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