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Recombinant Human Proprotein convertase subtilisin/kexin type 9(PCSK9)

Recombinant Human Proprotein convertase subtilisin/kexin type 9(PCSK9)

Item no.	CSB-AP005741HU-10
Manufacturer	Cusabio
Amount	10ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Other Recombinant Protein
Subdivision	Others
Research Areas	Cardiovascular
Uniprot NO.	Q8NBP7
Gene Names	PCSK9
Source	Mammalian cell
Expression Region	31-152aa & 153-692aa
Sequence	QEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFH RCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQA QAARRGYLTKILHVFHGLLPGFLVKMSGDLLELAL KLPHVDYIEEDSSVFAQ & SIPWNL ERITPPRY RADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVM VTDFENVPEEDGTRFHRQASKCDSHGTHLAGVVSG RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFI RKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLAR AGVVLVTAAGNFRDDACLYSPASAPEVITVGATNA QDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCS TCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAEL RQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPP STHGAGWQLFCRTVWSAHSGPTRMATAVARCAPDE ELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFG GEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVH CHQQGHVLTGCSSHWEVEDLGTHKPPVLRPRGQPN QCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQ VTVACEEGWTLTGCSALPGTSHVLGAYAVDNTCVV RSRDVSTTGSTSEGAVTAVAICCRSRHLAQASQEL
Protein Description	Full Length
Tag Info	C-terminal Avi-tagged
Mol. Weight	14 & 59 kDa
Biological Activity	The ED50 as determined by its ability to bind Human LDLR in functional ELISA is less than 200 ug/ml
Purity	Greater than 95% as determined by SDS-PAGE.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um Filtered 50 mM HEPES, 150 mM NaCl, 20% Glycerol, pH 7.4
Alias	Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1
Relevance	Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
Function	Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members
Involvement in disease	Hypercholesterolemia, autosomal dominant, 3 (HCHOLA3)
Subcellular Location	Cytoplasm, Secreted, Endosome, Lysosome, Cell surface, Endoplasmic reticulum, Golgi apparatus
Protein Families	Peptidase S8 family
Tissue Specificity	Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
Paythway	Cholesterolmetabolism

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Amount: 10ug

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