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Recombinant Human Interleukin-1 beta(IL1B)

Recombinant Human Interleukin-1 beta(IL1B)

Item no.	CSB-AP004221HU-50
Manufacturer	Cusabio
Amount	50ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Interferon
Research Areas	Immunology
Uniprot NO.	P01584
Gene Names	IL1B
Source	E.coli
Expression Region	117-269aa
Sequence	APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQD MEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLS CVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIE INNKLEFESAQFPNWYISTSQAENMPVFLGGTKGG QDITDFTMQFVSS
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	17.5 kDa
Biological Activity	The ED50 as determined by its ability to induce NFKB reporter gene expression in HEK 293 cell line is typically 142 pg/mL
Purity	Greater than 95% as determined by SDS-PAGE.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	Lyophilized from a 0.2 um filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias	Interleukin-1 beta; Catabolin; IL1F2; IL1B.
Relevance	IL1B belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Function	Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Subcellular Location	Cytoplasm, cytosol, Lysosome, Secreted, exosome, Secreted
Protein Families	IL-1 family
Tissue Specificity	Expressed in activated monocytes/macrophages (at protein level).
Paythway	MAPKsignalingpathway

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Amount: 50ug

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