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Recombinant Human Insulin-like growth factor-binding protein 5 protein(IGFBP5) (Active)

Recombinant Human Insulin-like growth factor-binding protein 5 protein(IGFBP5) (Active)

Item no.	CSB-AP002501HU-1
Manufacturer	Cusabio
Amount	1mg
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>96% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Cancer
Uniprot NO.	P24593
Uniprot Entry Name	IBP5_HUMAN
Gene Names	IGFBP5, IBP5
Source	E.Coli
Expression Region	21-272aa
Sequence	LGSFVHCEPC DEKALSMCPP SPLGCELVKE PG CGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQ DEEKPL HALLHGRGVC LNEKSYREQV KIERDS REHE EPTTSEMAEE TYSPKIFRPK HTRISELK AE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV P RAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWC VDKYGMK LPGMEYVDGD FQCHTFDSSN VE
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	28.6 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4 ug/ml, corresponding to a specific activity of ? 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II.
Purity	>96% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.0 , lyophilized
Alias	IBP-5, IGFBP-5
Relevance	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
PubMed ID	1850258; 1709938; 7511611; 15489334; 1850257; 9883900; 22117064; 26091039; 9822601
Function	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular Location	Secreted
Tissue Specificity	Osteosarcoma, and at lower levels in liver, kidney and brain.
Tag Information	Tag-Free

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