Item no. |
CSB-AP002501HU-1 |
Manufacturer |
Cusabio
|
Amount |
1mg |
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>96% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Classification |
Cytokine |
Subdivision |
Growth Factor |
Research Areas |
Cancer |
Uniprot NO. |
P24593 |
Uniprot Entry Name |
IBP5_HUMAN |
Gene Names |
IGFBP5, IBP5 |
Source |
E.Coli |
Expression Region |
21-272aa |
Sequence |
LGSFVHCEPC DEKALSMCPP SPLGCELVKE PG CGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQ DEEKPL HALLHGRGVC LNEKSYREQV KIERDS REHE EPTTSEMAEE TYSPKIFRPK HTRISELK AE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV P RAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWC VDKYGMK LPGMEYVDGD FQCHTFDSSN VE |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
28.6 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit IGF-II induced proliferation of MCF-7 cells is less than 0.4 ug/ml, corresponding to a specific activity of ? 2500 IU/mg in the presence of 15 ng/ml of rHuIGF-II. |
Purity |
>96% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.0 , lyophilized |
Alias |
IBP-5, IGFBP-5 |
Relevance |
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
PubMed ID |
1850258; 1709938; 7511611; 15489334; 1850257; 9883900; 22117064; 26091039; 9822601 |
Function |
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
Subcellular Location |
Secreted |
Tissue Specificity |
Osteosarcoma, and at lower levels in liver, kidney and brain. |
Tag Information |
Tag-Free |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.