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Recombinant Human Fibroblast growth factor 21 protein(FGF21) (Active)

Recombinant Human Fibroblast growth factor 21 protein(FGF21) (Active)

Item no.	CSB-AP002471HU-1
Manufacturer	Cusabio
Amount	1mg
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>96% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Growth Factor
Research Areas	Cancer
Uniprot NO.	Q9NSA1
Uniprot Entry Name	FGF21_HUMAN
Gene Names	FGF21, UNQ3115/PRO10196
Source	E.Coli
Expression Region	29-209aa
Sequence	HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AH LEIREDGT VGGAADQSPE SLLQLKALKP GVIQ ILGVKT SRFLCQRPDG ALYGSLHFDP EACSFR ELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDP AP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	19.4 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 ug/ml, corresponding to a specific activity of ? 2.0 x 103 IU/mg in the presence of 5 ug/ml of rMuKlotho-beta and 10 ug/ml of heparin.
Purity	>96% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	FGF-21,
Relevance	Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. {ECO:0000269\|PubMed:15902306, ECO:0000269\|PubMed:17623664}.
PubMed ID	10858549; 12975309; 15489334; 15340161; 15902306; 17623664; 18829467; 19117008; 20094046
Function	Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
Subcellular Location	Secreted
Protein Families	Heparin-binding growth factors family
Paythway	MAPKsignalingpathway
Tag Information	Tag-Free

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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