Item no. |
CSB-AP001811HU-100 |
Manufacturer |
Cusabio
|
Amount |
100ug |
Quantity options |
1mg
10ug
100ug
2ug
250ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Classification |
Cytokine |
Subdivision |
Interleukin |
Research Areas |
Immunology |
Uniprot NO. |
P29459 |
Uniprot Entry Name |
IL12A_HUMAN |
Gene Names |
IL12A, NKSF1 |
Source |
Mammalian cell |
Expression Region |
23-219aa&23-328aa |
Sequence |
p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DI TKDKTSTV EACLPLELTK NESCLNSRET SFIT NGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEF KTMN AKLLMDPKRQ IFLDQNMLAV IDELMQAL NF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: IW ELKKDVYV VELDWYPDAP GEMVVLTCDT PEED GITWTL DQSSEVLGSG KTLTIQVKEF GDAGQY TCHK GGEVLSHSLL LLHKKEDGIW STDILKDQ KE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG D NKEYEYSVE CQEDSACPAA EESLPIEVMV DAV HKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLK NSRQV EVSWEYPDTW STPHSYFSLT FCVQVQG KSK REKKDRVFTD KTSATVICRK NASISVRAQ D RYYSSSWSEW ASVPCS |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
75.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using PHA-activated human T lymphoblasts is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 x 107 IU/mg. |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
IL-12A, CLMF p35, IL-12 subunit p35, NK cell stimulatory factor chain 1, NKSF1 |
Relevance |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
PubMed ID |
1673147; 1674604; 16641997; 2204066; 1374259; 16548883; 10899108 |
Function |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. |
Subcellular Location |
Secreted |
Protein Families |
IL-6 superfamily |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
Tag-Free |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.