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Recombinant Human Interleukin-12 subunit alpha protein(IL12A) (Active)

Recombinant Human Interleukin-12 subunit alpha protein(IL12A) (Active)

Item no.	CSB-AP001811HU-1
Manufacturer	Cusabio
Amount	1mg
Quantity options	1mg 10ug 100ug 2ug 250ug 500ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>95% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Interleukin
Research Areas	Immunology
Uniprot NO.	P29459
Uniprot Entry Name	IL12A_HUMAN
Gene Names	IL12A, NKSF1
Source	Mammalian cell
Expression Region	23-219aa&23-328aa
Sequence	p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DI TKDKTSTV EACLPLELTK NESCLNSRET SFIT NGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEF KTMN AKLLMDPKRQ IFLDQNMLAV IDELMQAL NF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: IW ELKKDVYV VELDWYPDAP GEMVVLTCDT PEED GITWTL DQSSEVLGSG KTLTIQVKEF GDAGQY TCHK GGEVLSHSLL LLHKKEDGIW STDILKDQ KE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG D NKEYEYSVE CQEDSACPAA EESLPIEVMV DAV HKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLK NSRQV EVSWEYPDTW STPHSYFSLT FCVQVQG KSK REKKDRVFTD KTSATVICRK NASISVRAQ D RYYSSSWSEW ASVPCS
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	75.0 kDa
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using PHA-activated human T lymphoblasts is less than 0.05 ng/ml, corresponding to a specific activity of ? 2.0 x 107 IU/mg.
Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	IL-12A, CLMF p35, IL-12 subunit p35, NK cell stimulatory factor chain 1, NKSF1
Relevance	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
PubMed ID	1673147; 1674604; 16641997; 2204066; 1374259; 16548883; 10899108
Function	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subcellular Location	Secreted
Protein Families	IL-6 superfamily
Paythway	Jak-STATsignalingpathway
Tag Information	Tag-Free

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