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Recombinant Human C-C motif chemokine 25 protein(CCL25) (Active)

Recombinant Human C-C motif chemokine 25 protein(CCL25) (Active)

Item no.	CSB-AP000981HU-500
Manufacturer	Cusabio
Amount	500ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human
Purity	>97% as determined by SDS-PAGE and HPLC.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Classification	Cytokine
Subdivision	Chemokine
Research Areas	Immunology
Uniprot NO.	O15444
Uniprot Entry Name	CCL25_HUMAN
Gene Names	CCL25, SCYA25, TECK
Source	E.Coli
Expression Region	24-150aa
Sequence	M+QGVFEDCCL AYHYPIGWAV LRRAWTYRIQ E VSGSCNLPA AIFYLPKRHR KVCGNPKSRE VQR AMKLLDA RNKVFAKLHH NTQTFQAGPH AVKKL SSGNS KLSSSKFSNP ISSSKRNVSL LISANSG
Protein Description	Full Length of Mature Protein
Tag Info	Tag-Free
Mol. Weight	14.3 kDa
Biological Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml.
Purity	>97% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Alias	Chemokine TECK, Thymus-expressed chemokine
Relevance	Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
PubMed ID	9285413; 14702039; 15057824; 15489334; 10229797; 23341447
Function	Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location	Secreted
Protein Families	Intercrine beta (chemokine CC) family
Tissue Specificity	Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Paythway	Chemokinesignalingpathway
Tag Information	Tag-Free

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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