Item no. |
CSB-AP000981HU-500 |
Manufacturer |
Cusabio
|
Amount |
500ug |
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Classification |
Cytokine |
Subdivision |
Chemokine |
Research Areas |
Immunology |
Uniprot NO. |
O15444 |
Uniprot Entry Name |
CCL25_HUMAN |
Gene Names |
CCL25, SCYA25, TECK |
Source |
E.Coli |
Expression Region |
24-150aa |
Sequence |
M+QGVFEDCCL AYHYPIGWAV LRRAWTYRIQ E VSGSCNLPA AIFYLPKRHR KVCGNPKSRE VQR AMKLLDA RNKVFAKLHH NTQTFQAGPH AVKKL SSGNS KLSSSKFSNP ISSSKRNVSL LISANSG |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
14.3 kDa |
Biological Activity |
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10 ng/ml. |
Purity |
>97% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
Chemokine TECK, Thymus-expressed chemokine |
Relevance |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
PubMed ID |
9285413; 14702039; 15057824; 15489334; 10229797; 23341447 |
Function |
Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
Subcellular Location |
Secreted |
Protein Families |
Intercrine beta (chemokine CC) family |
Tissue Specificity |
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine. |
Paythway |
Chemokinesignalingpathway |
Tag Information |
Tag-Free |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.