Item no. |
CSB-AP000011HU-1 |
Manufacturer |
Cusabio
|
Amount |
1mg |
Quantity options |
1mg
10ug
100ug
20ug
250ug
50ug
500ug
|
Category |
|
Type |
Proteins Recombinant |
Format |
Lyophilized powder |
Specific against |
Human |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Available |
|
Classification |
Hormone |
Subdivision |
Hormone |
Research Areas |
Signal Transduction |
Uniprot NO. |
P01241 |
Uniprot Entry Name |
SOMA_HUMAN |
Gene Names |
GH1 |
Source |
E.Coli |
Expression Region |
27-127aa |
Sequence |
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FE EAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNR EETQQK SNLELLRISL LLIQSWLEPV QFLRSV FANS LVYGASDSNV YDLLKDLEEG IQTLMGRL ED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F |
Protein Description |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Mol. Weight |
22.0 kDa |
Biological Activity |
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 lymphoma cells is less than 0.1 ng/ml, corresponding to a specific activity of ? 1.0 x 107 IU/mg. |
Purity |
>98% as determined by SDS-PAGE and HPLC. |
Endotoxin |
Less than 1.0 EU/ug as determined by LAL method. |
Storage Buffer |
0.2 um filtered PBS, pH 7.4 , lyophilized |
Alias |
Growth hormone, GH-N, Growth hormone 1, Pituitary growth hormone, |
Relevance |
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
PubMed ID |
386281; 377496; 6269091; 7169009; 2744760; 18473352; 16625196; 10931946; 15489334; 3912261; 5810834; 5144027; 4675454; 5279046; 5279528; 7462247; 7356479; 7028740; 8364549; 14997482; 10393484; 16807684; 3447173; 1549776; 7984244; 8943276; 8552145; 9152628; 9276733; 10391209; 11502836; 12655557; 15001589; 15713716; 17519310 |
Function |
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
Involvement in disease |
Growth hormone deficiency, isolated, 1A (IGHD1A); Growth hormone deficiency, isolated, 1B (IGHD1B); Kowarski syndrome (KWKS); Growth hormone deficiency, isolated, 2 (IGHD2) |
Subcellular Location |
Secreted |
Protein Families |
Somatotropin/prolactin family |
Paythway |
Jak-STATsignalingpathway |
Tag Information |
Tag-Free |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.