Item no. |
CSB-PA883379ESR2HU |
Manufacturer |
Cusabio
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Format |
liquid |
Applications |
WB, ELISA |
Specific against |
Human, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
AMPK gamma3,AMPK subunit gamma-3,PRKAG3,AMPKG3 |
Available |
|
Alias |
AMPK gamma3, AMPK subunit gamma-3, PRKAG3, AMPKG3 |
Uniprot ID |
Q9UGI9 |
Immunogen |
Recombinant human 5'-AMP-activated protein kinase subunit gamma-3 protein (1-210aa) |
Tested applications |
ELISA, WB; Recommended dilution:WB:1:500-2000 |
Background |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. |
Conjugate |
Non-conjugated |
Stroage Buffer |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Stroage |
Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze. |
Purity |
Antigen Affinity Purified |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.