Item no. |
CSB-PA868326LA01HU-50ug |
Manufacturer |
Cusabio
|
Amount |
50ug |
Quantity options |
100ug
20ug
50ug
|
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
IF, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DKFZP586D211 antibody; hPot 1 antibody; hPot1 antibody; POT 1 antibody; POT1 antibody; POT1 like telomere end-binding protein antibody; POT1 protection of telomeres 1 homolog antibody; POT1-like telomere end-binding protein antibody; POTE1_HUMAN antibody; Protection of telomeres 1 antibody; Protection of telomeres 1 homolog (S. pombe) antibody; Protection of telomeres protein 1 antibody, Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein), POT1 |
Similar products |
POT1, Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein) |
Available |
|
Immunogen Species |
Human |
UniprotID |
Q9NUX5 |
Immunogen |
Recombinant Human Protection of telomeres protein 1 protein (250-432AA) |
Applications info |
ELISA, IHC, IF, Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
IHC:1:20-1:200 |
Dilution ratio 3 |
IF:1:50-1:200 |
Background |
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Epigenetics and Nuclear Signaling, Cancer |
Initial Research Areas |
Epigenetics and Nuclear Signaling |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.