Item no. |
CSB-PA01915C0Rb |
Manufacturer |
Cusabio
|
Amount |
100ug |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
WB, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Metalloprotease RGD disintegrin protein,Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15,Metargidin,ADAM15,MDC15 |
Available |
|
Uniprot ID |
Q13444 |
Immunogen |
Recombinant human Disintegrin and metalloproteinase domain-containing protein 15 protein |
Conjugate |
FITC conjugated |
Alias |
Metalloprotease RGD disintegrin protein, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15, Metargidin, ADAM15, MDC15 |
Relevance |
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. |
Buffer |
Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Form |
Liquid |
Stroage |
Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze. |
Purity |
Caprylic Acid Ammonium Sulfate Precipitation purified |
Research Area |
Cancer |
References |
"Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence."Kraetzschmar J., Lum L., Blobel C.P. J. Biol. Chem. 271:4593-4596(1996) |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.