Item no. |
CSB-PA015422ED01HU |
Manufacturer |
Cusabio
|
Amount |
100ug |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Nicotinamide phosphoribosyltransferase,NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin,NAMPT,PBEF,PBEF1 |
Available |
|
Background |
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity). |
Alias |
Nicotinamide phosphoribosyltransferase, NAmPRTase, Nampt, Pre-B-cell colony-enhancing factor 1, Pre-B cell-enhancing factor, Visfatin, NAMPT, PBEF, PBEF1 |
Uniprot |
P43490 |
Immuongen |
Recombinant Human Nicotinamide phosphoribosyltransferase protein (1-280AA) |
Counjugation |
Biotin |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Storage |
Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze. |
Purification |
>95%, Protein G purified |
Abbreviation |
Nicotinamide phosphoribosyltransferase |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.