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Anti C9ORF72 (Poly-GA) pAb (Rabbit, Antiserum)

Anti C9ORF72 (Poly-GA) pAb (Rabbit, Antiserum)

Item no.	CAC-TIP-C9-P01
Manufacturer	Cosmobio
Amount	50 ul
Category	Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Applications	ELISA, IHC(p)
Manufacturer - Category	Research Area/Disease/Frontotemporal dementia/Primary Antibodies; Research Area/Neurobiology/Neurodegeneration/Primary Antibodies; Research Area/Disease/Amyotrophic Lateral Sclerosis/Primary Antibodies; Antibodies/Primary Antibodies/Neurodegeneration; Antibodies/Neurodegeneration/Primary Antibodies; Antibodies/Abs For Paraffin Embedded Tissue/Neurodegeneration; Antibodies/Neurodegeneration/Abs For Paraffin Embedded Tissue; Research Area/Disease/Amyotrophic Lateral Sclerosis/Abs For Paraffin Embedded Tissue; Research Area/Disease/Frontotemporal dementia/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Neurodegeneration/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Post Translational Modification & Processing/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Post Translational Modification & Processing/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Lysosomes/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Lysosomes/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Stress Granules/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Stress Granules/Primary Antibodies; Research Area/Organelles & Subcellular Structures/P Bodies/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/P Bodies/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Autophagosomes/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Axons/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Autophagosomes/Primary Antibodies; Research Area/Neurobiology/Axons/Primary Antibodies; Research Area/Cell Biology/Autophagy/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Exocytosis/Primary Antibodies; Research Area/Neurobiology/Dendrites/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Dendrites/Primary Antibodies; Research Area/Neurobiology/Synapses/Abs For Paraffin Embedded Tissue; Research Area/Neurobiology/Synapses/Primary Antibodies; Research Area/Cell Biology/Autophagy/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Endosomes/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Exocytosis/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Endosomes/Primary Antibodies; Research Area/Organelles & Subcellular Structures/Microfilaments/Abs For Paraffin Embedded Tissue; Research Area/Organelles & Subcellular Structures/Microfilaments/Primary Antibodies; Research Area/Cell Biology/Protein Transport/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Protein Transport/Primary Antibodies; Research Area/Cell Biology/Signal Transduction/Abs For Paraffin Embedded Tissue; Research Area/Cell Biology/Signal Transduction/Primary Antibodies
Maker	CAC
Short Description	Anti-C9ORF72 (Poly-GA) pAb — prepared from rabbits immunized with poly (GA)8 — recognizes poly (GA) dipeptide repeat proteins. \\Validated for ELISA and IHC(p), this antibody is useful for immunohistochemical and biochemical studies of C9ORF72 (Poly-GA) dipeptide species in diseased brains.
Description	Anti-C9ORF72 (Poly-GA) pAb — prepared from rabbits immunized with poly (GA)8 — recognizes poly (GA) dipeptide repeat proteins. Validated for ELISA and IHC(p), this antibody is useful for immunohistochemical and biochemical studies of C9ORF72 (Poly-GA) dipeptide species in diseased brains. In 2011 hexanucleotide expansions in the C9ORF72 gene were identified in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). GGGGCC expansions are characterized pathologically by the presence of TDP-43 negative and p62 positive inclusions in granule cells of the cerebellum and in cells of the dentate gyrus and CA4 area of the hippocampus. It was reported that these inclusions included dipeptide repeat proteins, poly-GA, poly-GR and poly-GP, arising from a putative non-ATG initiated sense translation of the GGGGCC expansion. These antibodies are powerful tools for IHC analysis of neurodegenerative diseases. Specifications Product type primary antibody Immunogen poly (GA)8 Raised in rabbit Source anti-serum Form liquid anti-serum with 0.1% NaN3 as a preservative Volume 50 uL Label unlabeled Specificity poly (GA)8 Cross reactivity human Storage below -20° C. (below -70° C for prolonged storage). Aliquot to avoid cycles of freeze/thaw. Recommended dilutions ELISA 1/500-1/2000 Immunohistochemistry 1/500-1/2000 Other applications have not been tested Optimal dilutions/ concentrations should be determined by the end user. References David MA Mann, et al. Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neuron disease associated with expansions in C9ORF72. Acta Neuropathologica Communications (2013) 1:68. PMID 24252525 Tan RH, et al. Cerebellar neuronal loss in als cases with ATXN2 intermediate repeat expansions. Ann Neurol. 2015 Nov 24. doi: 10.1002/ana.24565. PMID:26599997 Davidson Y, et al. Neurodegeneration in Frontotemporal Lobar Degeneration and Motor Neuron Disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins. Neuropathol Appl Neurobiol. 2015 Nov 5. doi: 10.1111/nan.12292. PMID: 26538301 Baborie A, et al. Accumulation of dipeptide repeat proteins predates that of TDP-43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene. Neuropathol Appl Neurobiol. 2015 Aug; 41(5):601-12. doi: 10.1111/nan.12178. Epub 2015 Apr 30. PMID: 25185840 Davidson YS, et al. Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72. Acta Neuropathol Commun. 2014 Jun 20; 2:70. doi: 10.1186/2051-5960-2-70. PMID: 24950788 Konno T, et al. C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS. Neuropathol Appl Neurobiol. 2014 Oct; 40(6):783-8. doi: 10.1111/nan.12157. No abstract available. PMID: 24861677
Clonality	Polyclonal

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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