Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8)

Antibodies/Primary Antibodies/Detoxification; Antibodies/Detoxification/Primary Antibodies; Research Area/Organs & Organ Systems/Liver/Primary Antibodies; Research Area/Systemic Physiology/Detoxification/Primary Antibodies

UniPlot Summary
Function// Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Subunit structure// Homodimer.
Subcellular location// Cytoplasm.
Tissue specificity// Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Sequence similarities// Belongs to the aldo/keto reductase 2 family.
Reference
1. "cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily,
AKR7A3." Knight L.P.et al. Carcinogenesis 20:1215-1223(1999) [PubMed: 10383892] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE
[MRNA], CHARACTERIZATION, VARIANTS MET-138; ASP-215 AND ALA-323. Tissue: Liver.
2. "Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells." Praml C.et
al. Oncogene 22:4765-4773(2003) [PubMed: 12879023] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY,
VARIANTS ASP-215 AND ALA-323.
3. "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G. et al. Nature 441:315-321(2006) [PubMed:
16710414] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

Monoclonal