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Defactinib

Defactinib

Item no.	CT-DEFA-10
Manufacturer	ChemieTek
Amount	10mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VS-6063
Available
CASRN	1073154-85-4
Synonym	VS-6063
Brief Description	Focal adhesion kinase (FAK), a non-receptor tyrosine kinase , orchestrates cell signaling through integrins and growth factor receptors and plays important roles in tumorigenesis. Defactinib is a potent, selective, and orally active FAK inhibitor with demonstrated tolerability and preliminary clinical activity targeting cancer stem cells, working as a single agent as well as in combination with paclitaxel.
Solubility	Soluble in DMSO
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99% (HPLC at 214 and 254 nm)
Original QC Data	HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis
Shipping Conditions	Ambient Temp.
References	C. M. Vidal, et al., Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells, Mol Cancer Ther November 2013 12; C27

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 10mg

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