« Back
Home /
BIBW-2992

BIBW-2992

Item no.	CT-BW2992-200
Manufacturer	ChemieTek
Amount	200mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tovok, Afatinib
Available
CASRN	439081-18-2
Synonym	Tovok, Afatinib
Brief Description	BIBW2992 (Afatinib) is an ATP-competitive, small molecule irreversible inhibitor for EGFR/HER2, displaying inhibitory potency against EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2, with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
Solubility	Soluble in DMSO
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99.5% chem and optical purity (HPLC and Chiral HPLC)
Original QC Data	HPLC-MS, ¹HNMR, Chiral HPLC and Quatitative Elemental Analysis
Shipping Conditions	Ambient Temp.
References	1. Li, D. et al., BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models, Oncogene 2008, 27 (34), 4702-4711. 2. Minkovsky, N. et al., BIBW-2992, a dual receptor tyrosine kinase inhibitor for the treatment of solid tumors. Curr Opin Investig Drugs (December 2008), 9 (12), 1336-46.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 200mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 16 days

Compare

Add to wishlist

Recommend by mail