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NVP-BKM120

NVP-BKM120

Manufacturer	ChemieTek
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10mg
Item no.	CT-BKM120-10
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	Buparlisib
CASRN	944396-07-0
Synonym	Buparlisib
Brief Description	NVP-BKM120 (Buparlisib) is an orally bioavailable and selective pan-class I phosphatidylinositol-3 kinase (PI3K) inhibitor with in vitro IC50 values of 52 nM/166 nM/116 nM/262 nM for p110α /β /δ /γ isoforms, respectively. It is much less effective on inhibiting the class III PI3K Vps34 and mTOR, and has no effect on PI4Kβ . It is currently in clinical trials for cancer treatment.
Solubility	Soluble in DMSO
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99.5% (HPLC at 214 and 254 nm)
Original QC Data	HPLC-MS, ¹HNMR, and Quantitative Elemental Analysis
Shipping Conditions	Ambient Temp.
References	1.M. T. Burger, et al., Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer ACS Med. Chem. Lett., 2011, 2 (10), pp 774-779 2. S. M. Maira, et al., Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor, Mol Cancer Ther. 2012 Feb; 11(2):317-28 3. S. M. Brachmann, et al., Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations, Mol Cancer Ther. 2012 Aug; 11(8):1747-57

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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