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AZD3463

AZD3463

Item no.	CT-A3463-50
Manufacturer	ChemieTek
Amount	50mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
CASRN	1356962-20-3
Brief Description	Valsartan is a potent, selective and orally active AT1 receptor antagonist (Ki = 2.38 nM), with over 30, 000-fold selectivity over AT2 receptors. It is an investigational antihypertensive drug being studied for use in combination with AHU-377 (molar ratio: 1:1) (Our Prod No. CT-AHU377). The combination drug, known as LCZ696, is in clinical trials for the treatment of heart failure.
Solubility	Soluble in DMSO
Storage	Store at 0° C (short term), -20° C (long term), desiccated
Purity	>99% (HPLC at 214 and 254 nm)
Original QC Data	HPLC-MS, ¹HNMR
Shipping Conditions	Ambient Temp.
References	1. L. Criscione, et al, Pharmacological profile of Valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype, Br J Pharmacol, 1993, Oct; 110(2):761-71 2. S. Hanafy, et al, Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers, Br J Pharmacol, 2008 Jan; 153(1):90-9 3. A. A. Voors, et al., The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug. 22(8):1041-7.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50mg

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