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Dorsomorphin Hydrochloride

Dorsomorphin Hydrochloride

Item no.	CD0339-250
Manufacturer	Chemdea
Amount	250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BML-275 Hydrochloride, AMPK inhibitor
Available
Inhibitor Function	AMPK Inhibitor
Description	A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, Ki = 109 nM in the presence of 5 µ M ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCq, PKA, or JAK3. Blocks celluar activities induced by AICAr or Metformin. Induces weight loss by attenuating AMPK-mediated food intake in mice.
Purity	99% by HPLC.
CAS #	1219168-18-9
Solubility	DMSO (5 mg/mL) and water (50 mg/mL).
Molecular Formula	C₂₄H₂₅N₅O&bull, HCl
Molecular Weight	472.41
Notes	Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Reference	1. Yu, P.B., et al. Nat. Chem. Biol 2008, 4, 33 2. Kim, E.K., et al. J. Biol. Chem. 2004, 279, 19970 3. Inoki, K., et al. Cell 2003, 115, 577 4. Fryer, L.G., FEBS Lett. 2002, 531, 189 5. Zhou, G., et al. J. Clin. Invest. 2001, 108, 1167.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 9/6/2024