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PD173074

PD173074

Item no.	CD0172-250
Manufacturer	Chemdea
Amount	250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FGF/VEGF Receptor Tyrosine Kinase Inhibitor
Available
Inhibitor Function	FGV/VEGF Receptor Tyrosine Kinase Inh.
Description	A cell-permeable pyridopyrimidine compound that acts as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors (IC50 = 21.5 nM for FGFR1). It inhibits PDGFR and c-Src only at much higher concentration (IC50 = 17.6 µ M, 19.8 µ M, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 µ M. Shown to inhibit the autophosphorylation of endogenous FGFR1 (IC50 <5 nM) and overexpressed VEGFR2 (IC50 <200 nM) in NIH3T3 cells in vitro, and FGF- and VEGF-induced angiogenesis in mice in vivo.
Purity	99% by HPLC.
CAS #	219580-11-7
Solubility	DMSO (100 mg/mL).
Molecular Formula	C₂₈H₄₁N₇O₃
Molecular Weight	523.7
Notes	Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS.
Reference	1. Kunath, T., et al. Development 2007, 134, 2895 2. Stavridis, M.P., et al. Development 2007, 134, 2889 3. Zaragosi, L.E., et al. Stem Cells 2006, 24, 2412 4. St. Bernard, R., et al. Endocrinology 2005, 146, 1145 5. Koziczak, M., et al. Oncogene 2004, 23, 3501 6. Trudel, S., et al. Blood 2004, 103, 3521, 7. Skaper, S.D., et al. J. Neurochem. 2000, 75, 1520 8. Mohammadi, M., et al. EMBO J. 1998, 17, 5896.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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