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INS-1E cells

INS-1E cells

Item no.	C0018009
Manufacturer	Addexbio
Amount	One Frozen vial
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Cell Lines & Cell Culture Cell Lines By Organ Pancreatic Cancer
Type	Tumour Cells
Specific against	Rat (Rattus norvegicus)
Dry ice	Yes
Citations	1.Janjic D, Maechler P, et al. (1999). Free radical modulation of insulin release in INS-1 cells exposed to alloxan. Biochem. Pharmacol. 57, 639-648. 2. Andrzejewski D, Brown ML, Ungerleider N, Burnside A, Schneyer AL. Activins A and B Regulate Fate-Determining Gene Expression in Islet Cell Lines and Islet Cells From Male Mice. Endocrinology. 2015 Jul;156(7):2440-50. doi: 10.1210/en.2015-1167. PMID: 25961841 3. Huang Q, Merriman C, Zhang H, Fu D. Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells. J Biol Chem. 2017;292(10):4034-4043. PMID: 28130446 4. Carstensen-Kirberg M, Rohrig K, Niersmann C, Ouwens DM, Belgardt BF, Roden M, Herder C. Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E. PLoS One. 2019 Mar 28;14(3):e0213650. PMID: 30921355 5. Plecita-Hlavata L, Engstova H, Jeek J, Holendova B, Tauber J, Petraskova L, Ken V, Jeek P. Potential of Mitochondria-Targeted Antioxidants to Prevent Oxidative Stress in Pancreatic ?-cells. Oxid Med Cell Longev. 2019 May 21;2019:1826303. PMID: 31249641
ECLASS 10.1	32160890
ECLASS 11.0	32160890
UNSPSC	41106509
Available
Description	Disease: Insulinoma (Isolated clonal INS-1E cells from the parental INS-1 cells) Origin: Pancreatic Islets Species: Rattus Norvegicus Tissue: Pancreas Morphology: beta cells Properties: Adherent Medium: AddexBio-Optimized RPMI-1640 Medium(C0004-02) + 10% FBS + 0.05 mM 2-mercaptoethanol Subculture: 1:2 to 1:8 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37C Freezing Medium: Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility: Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens: HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Insulin Responsiveness: Respond to glucose within the physiological range. Relatively high insulin content. Related cells by Organ: AR-42J cells BxPc-3 cells Capan-1 cells MIA PaCa-2 cells E3LZ10.7 cells A10.7 cells INS-1 cells MIN-6 cells INS-1E cells
Storage condition	LN2
Manufacturers Category	Cell Lines

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: One Frozen vial

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Delivery expected until 3/14/2025

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