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MIN-6 cells

MIN-6 cells

Item no.	C0018008
Manufacturer	Addexbio
Amount	One Frozen vial
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Cell Lines & Cell Culture Cell Lines By Organ Pancreatic Cancer
Type	Tumour Cells
Specific against	Mouse (Murine, Mus musculus)
Dry ice	Yes
Citations	1.Ishihara, H., Asano, T., Tsukuda, K. et al. (1993). Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia 36(11), 1139-1145. 2. Bao L, Fu X, Si M, Wang Y, Ma R, Ren X, Lv H. MicroRNA-185 Targets SOCS3 to Inhibit Beta-Cell Dysfunction in Diabetes. PLoS One. 2015 Feb 6;10(2):e0116067. PMID: 25658748 3.Mayer C, Bergholdt R, Cucak H, Rolin BC, Sams A, Rosendahl A.Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without AffectingHbA1c in Type 2 Diabetic db/db Mice. PLoS One. 2015 Jul 10;10(7):e0131306. PMID: 26162095 4. Fortin JS, Benoit-Biancamano MO, C-Gaudreault R. Discovery of ethyl urea derivatives as inhibitors of islet amyloid polypeptide fibrillization and cytotoxicity. Can J Physiol Pharmacol. 2016 Mar;94(3):341-346. PMID: 26679837 5. Chang TJ, Tseng HC, Liu MW, Chang YC, Hsieh ML, Chuang LM. Glucose-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improvingmitochondrial function and suppressing prolonged AMPK activation.Sci Rep. 2016 Mar 21;6:23403. doi: 10.1038/srep23403. PMID: 26997114 6. Huang LP, Kirschke CP. Down-regulation of zinc transport 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin Journal of Endocrinology and Diabetes. 2016;3(1):1037. 7. Silvander JSG, Kvarnström SM, Kumari-Ilieva A, Shrestha A, Alam CM, Toivola DM. Keratins regulate beta-cell mitochondrial morphology, motility, and homeostasis. FASEB J. 2017 Oct;31(10):4578-4587. PMID: 28666985 8. Elliott AD, Bedard N, Ustione A, Baird MA, Davidson MW, Tkaczyk T, Piston DW. Hyperspectral imaging for simultaneous measurements of two FRET biosensors in pancreatic beta-cells. PLoS One. 2017 Dec 6;12(12):e0188789. doi: 10.1371/journal.pone.0188789. PMID: 29211763 9. Velasquez C, Vasquez JS, Balcazar N. In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic beta-Cells. Diabetes Metab J. 2017 Aug;41(4):303-315. doi: 10.4093/dmj.2017.41.4.303. PMID: 28868828
ECLASS 10.1	32160890
ECLASS 11.0	32160890
UNSPSC	41106509
Available
Description	Disease: Insulinoma (SV40 T-antigen induced cell immortalization) Origin: Pancreatic Islets Species: Mus musculus Tissue: Pancreas Morphology: beta cells Properties: Adherent Medium: AddexBio-Advanced Medium (C0003-04) + other components critical to the cell growth listed on the datasheet. Subculture: 1:2 to 1:3 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37C Freezing Medium: Culture medium supplemented with 20% (v/v) FBS and 7.5% (v/v) DMSO Biosafety Level: II Sterility: Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens: HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Insulin Responsiveness: Express glucokinase and Glut2. Related cells by Organ: AR-42J cells BxPc-3 cells Capan-1 cells MIA PaCa-2 cells E3LZ10.7 cells A10.7 cells INS-1 cells MIN-6 cells
Storage condition	LN2
Manufacturers Category	Cell Lines

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: One Frozen vial

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Delivery expected until 3/14/2025

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