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INS-1 cells

INS-1 cells

Item no.	C0018007
Manufacturer	Addexbio
Amount	One Frozen vial
Category	Oncology Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Cell Lines & Cell Culture Cell Lines By Organ Pancreatic Cancer
Type	Tumour Cells
Specific against	Rat (Rattus norvegicus)
Dry ice	Yes
Citations	1.Asfari, M., Janjic, D., Meda, P. et al. (1992). Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines. Endocrinology 130, 167-178. 2. Chang TJ, Tseng HC, Liu MW, Chang YC, Hsieh ML, Chuang LM. Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improvingmitochondrial function and suppressing prolonged AMPK activation.Sci Rep. 2016 Mar 21;6:23403. doi: 10.1038/srep23403. PMID: 26997114 3.Fortin JS, Benoit-Biancamano MO. Inhibition of islet amyloid polypeptide aggregation and associated cytotoxicity by nonsteroidal anti-inflammatory drugs. Can J Physiol Pharmacol. 2016 Jan;94(1):35-48. PMID: 26524404 4. Fortin JS, Benoit-Biancamano MO. In vitro evaluation of hypoglycemic agents to target human islet amyloid polypeptide: a key protein involved in amyloid deposition and beta-cell loss. Can J Diabetes. 2015 Oct;39(5):373-382. PMID: 25862064 5. Bronsart LL, Stokes C, Contag CH.Chemiluminescence Imaging of Superoxide Anion Detects Beta-Cell Function and Mass.PLoS One. 2016 Jan 11;11(1):e0146601. PMID: 26752052 6. Fortin JS, Benoit-Biancamano MO. Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization. Amyloid. 2015;22(3):194-202. PMID: 26300107 7. Lee SJC, Choi TS, Lee JW, Lee HJ, Mun D, Akashi S, Lee SW, Lim MH, Kim HI. Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper. Chem Sci. 2016;22:5398-5406. 8. Lombardi A, Trimarco B, Iaccarino G, Santulli G. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. Cell Commun Signal. 2017;15(1):47. doi: 10.1186/s12964-017-0203-0. PMID: 29132395 9. Wong JC, Vo V, Gorjala P, Fiscus RR. Pancreatic-beta-cell survival and proliferation are promoted by protein kinase G type I-alpha and downstream regulation of AKT/FOXO1. Diab Vasc Dis Res. 2017;14(5):434-449. doi: 10.1177/1479164117713947. PMID: 28631500 10. Ji J, Petropavlovskaia M, Khatchadourian A, Patapas J, Makhlin J, Rosenberg L, Maysinger D. Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in ??cells. J Cell Mol Med 2019 Feb 1. doi: 10.1111/jcmm.14172. PMID: 30710421
ECLASS 10.1	32160890
ECLASS 11.0	32160890
UNSPSC	41106509
Available
Description	Disease: Insulinoma (Radiation induced cell immortalization) Origin: Pancreatic Islets Species: Rattus Norvegicus Tissue: Pancreas Morphology: beta cells Properties: Adherent Medium: AddexBio-Optimized RPMI-1640 Medium(C0004-02) + 10% FBS + 0.05 mM 2-mercaptoethanol Subculture: 1:2 to 1:8 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37C Freezing Medium: Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility: Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens: HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Insulin Responsiveness: Respond to glucose within the physiological range. Relatively high insulin content. Related cells by Organ: AR-42J cells BxPc-3 cells Capan-1 cells MIA PaCa-2 cells E3LZ10.7 cells A10.7 cells INS-1 cells MIN-6 cells INS-1E cells
Storage condition	LN2
Manufacturers Category	Cell Lines

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: One Frozen vial

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