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MOLM-13 cells

MOLM-13 cells

Item no.	C0003003
Manufacturer	Addexbio
Amount	One Frozen vial
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Cell Lines & Cell Culture Cell Lines By Organ Heart & Blood Cancer
Type	Tumour Cells
Specific against	Human (Homo sapiens)
Dry ice	Yes
Citations	1. Fang J et al. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-?B gene network. Cell Rep. 2014;8(5):1328-1338. PMID:25199827 2. Qi W, Zhang W, Edwards H, Chu R, Madlambayan GJ, Taub JW, Wang Z, Wang Y, Li C, Lin H, Ge Y. Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo. Cancer Biol Ther. 2015;16(12):1784-1793. doi: 10.1080/15384047.2015.1095406. PMID:26529495 3. Montemurro, L., Tonelli, R., Fazzina, R., Martino, V., Marino, F., and Pession, A. Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. Cancer Genet Cytogenet, 154: 96-97, 2004. 4.Qi W, Xie C, Li C, Caldwell JT, Edwards H, Taub JW, Wang Y1, Lin H, Ge Y. CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells. J Hematol Oncol. 2014 Aug 1;7:53. PMID: 25084614 5. Luedtke DA, Niu X, Pan Y, Zhao J, Liu S, Edwards H, Chen K, Lin H, Taub JW, Ge Y. Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells. Signal Transduct Target Ther. 2017 Apr 7;2:17012. doi: 10.1038/sigtrans.2017.12. PMID: 29263915
ECLASS 10.1	32160890
ECLASS 11.0	32160890
UNSPSC	41106509
Available
Description	Disease: Acute myeloid leukemia (AML) Origin: Established from the peripheral blood Species: Homo sapiens Tissue: Blood Properties: Suspension Cytogenic data: Hyperdiploid karyotype Patient: Male, 20 yrs of age Medium: AddexBio-formulated RPMI-1640 Medium (C0004-01) + 20% FBS Subculture: Cultures can be maintained by the addition or replacement of fresh medium. Start new cultures at 1 X 10⁵ viable cells/ml. Subculture at 1 X 10⁶ cells/ml. Culture cells at 5% CO₂, 37C. Medium Renewal: Split saturated culture 1:2 to 1:3. Freezing Medium: Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility: Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens: HIV: Negative Hepatitis B: Negative Hepatitis C: Negative DNA Profile (STR): Amelogenin: X, Y; CSF1PO: 10; D13S317: 10, 11; D16S539: 10, 11; D5S818: 10, 11; D7S820: 10, 12; THO1: 7; TPOX: 8; vWA: 16, 17 Protein Expression: CD3 -, CD4 +, CD13 (+), CD14 -, CD15 +, CD19 -, CD33 +, CD34 -, cyCD68 +, HLA-DR - Mutations in MOLM-13 Cells Related cells by Organ: CCRF-CEM K562 LP-1 MOLM-13 RPMI-8226 U937 RAW 264.7
Storage condition	LN2
Manufacturers Category	Cell Lines

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C0003003-safety-datasheet.pdf