Recombinant Human ENO2

Recombinant Human Enolase 2 contains 434 amino acids and is purified by proprietary chromatographic techniques. Enolase 2 (ENO2) is a glycolytic isoenzyme which is situated in central and peripheral neurons and neuroendocrine cells. It is released into the cerebral spinal fluid when neural tissue is injured. ENO2 is 1 of the 3 enolase isoenzymes found in mammals. ENO2 isoenzyme is found in mature neurons and cells of neuronal origin. An exchange from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Neoplasms derived from neural or neuroendocrine tissue release Enolase 2 into the blood. ENO2 is a useful substance that has been detected in patients with certain tumors, such as neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma.

Sterile filtered clear solution containing 20 mM Tris, pH-7.5, + 0.1M KCl + 5 mM MgSO4.

Stable at 2-4C for 1 week. Store at -20C. For long term storage, aliquot and freeze working stocks. Avoid repeated freeze-thaw cycles.